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In addition, the extent of infiltration of neutrophil- and monocyte-derived macrophages at the site of liver injury, the balance between M1- and M2-type macrophages, the amount of pro-inflammatory Ly6C hi CX3CR1 lo to reparative Ly6C lo CX3CR1 hi macrophage transformation, and the number of DC64L low DC44 hi CD4 + T cells in the liver in the early stages of APAP hepatotoxicity might serve as predictors of the extent of liver injury and inflammation in APAP hepatotoxicity

PMC 11050313

Nature 505 , 223228 (2014)

At his 1 month follow up, the patient reported that the rash had been continuing to spread and now involved his chest, legs, and arms (Figure 2)