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The binding of VEGF-A to VEGFR 2 (predominantly found on EC of blood vessels) leads to angiogenesis, whereas VEGF-C and D preferentially bind to VEGFR-3, expressed predominantly on lymphatic EC, resulting in the proliferation of lymphatic vessels [23]

90 HDAC5 has also been implicated in adult neurogenesis
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Indeed, overproduction of ROS is known to be crucial for carcinogenesis by promoting DNA oxidative damage, more specifically base alterations, abasic sites, and strand breaks [15]
