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These compounds promote increased extracellular glycine in the central nervous system, leading to the recovery of spinal inhibitory glycinergic function, which is important for pain control

Prior to the experiment, the animals underwent a two-week acclimatisation period, during which they were provided unrestricted access to standard laboratory chow and clean drinking water ad libitum

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[88] reported that the diurnal expression of Klf4 was lower in aged macrophages than in young macrophages and that the loss of Klf4 expression was accompanied by circadian rhythm disruption in the phagocytic activity of macrophages, indicating that the circadian rhythm was associated with agingrelated changes in macrophage phagocytosis