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In order to be placed on the European market, these compounds have to undergo a complex pre-market safety assessment procedure carried out by the European Food Safety Authority (EFSA), which includes detailed toxicological analyses, including genotoxicity testing, determination of the No Observed Adverse Effect Level (NOAEL), stability and estimated exposure studies, analysis of nutritional relevance, potential interactions with other nutrients, allergenicity risk assessment, and analysis of cumulative intake from all dietary sources [435]