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At the same time, size/shape biases uptake and endo-lysosomal routing (hence where GPX4/system Xc can be engaged), and surface chemistry/protein corona modulate cystine/GSH availability and GPX4 vulnerability (Figure 5)
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Numerous studies have demonstrated that natural products possess significant pharmacological properties, including immunomodulatory, anti-allergic, anti-inflammatory, and antioxidant effects (Chen et al

according to available reports, adverse effects were rarely observed in clinical practice [63,64,65,72]
Godet D, Marie P
