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PMC 2583103

Further, it does not imply that the Military Health System requires that use by DoD health care practitioners or considers it to be the standard of care. Rather, the inclusion in CPGs of off-label uses is to inform the clinical judgment of the responsible health care practitioner by providing information regarding potential risks and benefits of treatment alternatives

Medications for the treatment of dopaminergic symptoms include encompassing DA replacement therapy, peripheral 3,4-Dihydroxyphenylalanine (DOPA) decarboxylase inhibitors (DCI), DA receptor (DR) agonists, MAO-B inhibitors, and catechol-O-methyltransferase (COMT) inhibitors

Of note, GFAP is produced by activated astroglia that release ROS and pro-inflammatory mediators, creating a vicious cycle between oxidative stress and inflammation and hence playing a vital role in neuroinflammation with its subsequent neuronal apoptosis and hence neuronal damage (Colombo and Farina 2016)