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Mice were checked twice a week by a veterinarian responsible for animal welfare monitoring for signs of sufferance such as weight loss, decreased water and food consumption, poor hair coat, decreased activity levels accordingly to the guidelines for a correct laboratory practice and signs of poor quality of life

Statistical tests are based on two-sided Wald tests using Kenward-Roger degrees of freedom when comparing pairs of estimated marginal means extracted from the linear mixed model

The cyst size can be as small as a pea or as big as a dime

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