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Previous studies have revealed that PIK3CA mutations reprogram glutamine metabolism by upregulating the expression of glutamate pyruvate transaminase (GPT) 2, thereby increasing glutamine dependency in CRC cells [101]

This process results in increased levels of pro-inflammatory cytokines, including TNF- and IL-23, which facilitate osteoclastogenesis, RANKL expression, and the activation of myofibroblasts

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While the flu vaccine is generally safe, some individuals experience neuropathic symptoms like numbness, tingling, or weakness due to an immune system response or nerve irritation from the injection