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Indeed, if we replace the models of two c-METs from our structure of c-MET/HGF holo-complex to the N-terminus disordered c-MET, the distance between the two IPT2 domains is increased from 20 to 44 , suggesting that the compact c-MET is not in an ideal conformation for activation, which supports our hypothesis

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When tissue is damaged, its presence tells the body to activate fibroblasts, lay down new collagen and elastin, recruit antioxidant defences, and dampen inflammation