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However, the L-Carnitine group had a greater increase in carotid atherosclerotic stenosis of 9.3% (p=0.02) compared to the placebo group.[15] Important Takeaway Researchers noted that while there was not a significant increase in total plaque volume following six months of L-carnitine supplementation, their findings suggest potential harm with L-Carnitine supplements, both for worsening cardiometabolic risk factors (i.e., LDL-C) and for atherosclerosis progression (i.e., stenosis), potentially contributing to arterial plaque