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Metformin can interfere with the absorption of vitamin B12 in the small intestine, leading to lower B12 levels over time

Full cartilage regrowth remains unproven

10.1073/pnas.0813132106 [DOI] [PMC free article] [PubMed] [Google Scholar] 33.Thomas DT et al

While not establishing conclusive evidence, studies have consistently shown how raising vitamin B12 levels can positively impact depression symptoms
