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Microglia activation is usually followed by proliferation and release of pro-inflammatory cytokines such as TNF-, IL-1 and IL-6 [48], while there is strong evidence that this inflammatory state can lead to neuronal death in vitro and in vivo [49, 50]

The relevant data were extracted and summarized as impactful information on LC in the alleviation of CKD, therapeutic application, and future perspectives

It transports long-chain fatty acids into the mitochondria, the powerhouse of cells, where these fats are oxidized and used to create energy

Table 15 shows the studies in this review that investigated the remission effect of LC supplementation in patients with MS