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At 24, 48 and 72 hours, glutathione synthetase activity increased in susceptible plants, but the increase was of a much smaller magnitude in comparison with that observed in resistant plants

In an extended view, in the homocysteine degradation process, NAD + is a cofactor of 5,10-methylenetetrahydrofolate reductase (MTHFR), which catalyzes the reduction of 5,10-methyleneTHF into 5-methyltetrahydrofolate [45]

It is important to note that few studies have examined omics biomarkers in relationship to existing clinical criteria, such as coma or a constellation of clinical and laboratory findings (i.e., Kings College Criteria) currently in use by clinical practitioners as a prognostic indicator