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Notably, an enzyme detoxifying PAP into AMP known as FRY1/SAL1 is localized in chloroplasts (Estavillo et al., 2011), and therefore the transport of PAP into chloroplasts is both logical and essential for the cell

The enzyme cytochrome P450, involved in the metabolism of xenobiotics and endogenous compounds, can leak electrons to oxygen during its catalytic cycle, producing superoxide radicals [60]
What to know about L-carnitine from Medical News Today , medically reviewed by Angela M

The resulting accumulation of 7-ketocholesterol (7-KC), a toxic oxysterol enriched in drusen, contributes to oxidative stress, inflammation, and RPE degeneration in AMD
