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Curcumin may help to soothe inflammation due to everyday activity and promotes a healthier daily inflammatory response throughout the body, but especially in the joints

Neurosci Biobehav Rev 37:28872899 Liu D, Li S, Gong L, Yang Y, Han Y, Xie M, Zhang C (2019) Suppression of microRNA-141 suppressed p53 to protect against neural apoptosis in epilepsy by SIRT1 expression

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We propose a cellular model of CVS in which an aberrant ion gradient begets mitochondrial dysfunction which begets further anomalous ion gradients, etc., forming a pathogenic vicious cycle leading to cellular hyperexcitability (Figure 1)