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IGF-1 elevation is the primary mechanism through which full HGH increases the risk of insulin resistance, fluid retention, and certain growth-related effects at high doses

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It is naturally available in animal products, but deficiencies can occur due to dietary restrictions, malabsorption issues, or certain health conditions

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Some patients must continue to take supplements or receive injections for life depending on the reason for the deficiency

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Mol Ther Nucleic Acids (2018) 11:45567

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