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Therefore, the actual transport mechanism, i.e., symport and/or antiport is a still an open question: it can be speculated that OCTN2 may show different transport features according to isoforms and to the tissue in which it is expressed (Pochini et al., 2013)

Thus there are three thiokinases each specific for short, intermediate and long carbon chains

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This concern was further underscored by the SYRCLE RoB assessment, which identified high rates of unclear reporting in selection and performance bias domains (e.g., allocation concealment, randomised housing, and caregiver blinding), highlighting the need for more rigorous and standardised reporting practices in preclinical BBB research