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NAC may ameliorate the cognitive behavioral impairments induced by chronic ethanol exposure in APP/PS1 mice To explore the approach for ameliorating cognitive behavioral impairments induced by ethanol exposure in APP/PS1 mice, N-acetylcysteine (NAC), a well-known antioxidant was employed (Fig

Gut microbiota is involved in the synthesis of biological metabolites in the digestive tract [53]

Advanced molecular studies reveal that FOXO4-DRI promotes p53 nuclear exclusion and subsequent mitochondrial targeting, where p53 interacts with BCL-2 family proteins to promote mitochondrial outer membrane permeabilization and cytochrome c release

There is some controversy as to whether peripheral Ang II can modulate ACTH secretion