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Targeting ROS production through inhibition of NADPH oxidases
ROS also enhance their proliferation via two mechanisms: either by damaging biological molecules, leading to gene mutation and inflammation, or through abnormal oxidative stress redox signaling, which distorts signaling pathways and drives cancer progression
Shoumariyeh T
Apigenin sensitizes doxorubicin-resistant hepatocellular carcinoma BEL-7402/ADM cells to doxorubicin via inhibiting PI3K/Akt/Nrf2 pathway
