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91 ) and handled in compliance with relevant international guidelines (Policy on Humane Care and Use of Laboratory Animals and American Veterinary Medical Association, Embryos were injected at the 1-cell stage into the yolk immediately below the cell using a gas-driven microinjection apparatus (MPPI-2 Pressure Injector, Applied scientific Instrumentation

Caficrestat acts as an aldose reductase (AR) inhibitor

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Serotonin Synthesis BH4 is a cofactor in the conversion of tryptophan into 5-hydroxytryptophan (5-HTP)
