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doi: 10.2119/molmed.2015.00187

Research indicates that IGF-1 LR3's sustained receptor activation leads to prolonged Akt phosphorylation and enhanced mTOR-mediated translation initiation in cell culture systems

[DOI] [PubMed] [Google Scholar] 564

[] Overproduction of ROS caused by exposure to heavy metals begins from cellular metabolism at the mitochondria and eventually reaches all cellular components and tissues which causes oxidative stress which then can result in the apoptosis of cells
