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In 2006, as part of a larger revision, the Green Frog was removed from Rana and assigned to Lithobates , touching off a lively debate on whether the revision was justified and whether Lithobates should be recognized as a genus or as a subgenus within Rana
Continuous use year-round at maintenance doses (0.5mg twice weekly) has been reported in research contexts for up to 24 months without tolerance development or cumulative adverse events beyond those seen in short-term protocols

Cheng, L

Falbo Susan Joy Falbo Joseph Fallon P'20 Kathleen M