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Microsomal cytochrome P450 enzymes (notably CYP2E1 in alcohol metabolism): These generate ROS as part of detoxification reactions and sometimes uncoupled electron-leak events

While both freezing and high heat are not recommended, short-term exposure to ambient temperature extremes during shipping is unlikely to degrade the integrity of this product due to its stable composition

From a systems perspective, anxiety disorders is characterized by abnormalities in neurotransmitter functions, neurotrophic signaling, the endocannabinoid system and HPA axis function and these alterations are further compounded by chronic inflammation and maladaptive immune responses (Cai et al., 2025)

307 , C25C38 (2014)