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In turn, overlaying the naphthyl groups of NACPA and NEIH positions the 3-COOH group extending from the isoxazole ring of NEIH such that it aligns with the distal COOH group of l-Glu and delineates a second lipophilic pocket occupied by the 2,4-dinitrophenyl moiety (Figure 5D and E)

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Barnard ND, Kahleova H, Holtz DN et al (2023) A dietary intervention for vasomotor symptoms of menopause: a randomized, controlled trial
