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An ideal OIPN agent should act as a multitarget agent to increase its neuropathy protective efficacy while not reducing the antitumor efficacy of the chemotherapy
The Myc oncogene family is under the regulation of BRD4, and there have been numerous in vitro and in vivo studies showing the effectiveness of BET inhibitor (BETi) against Myc-driven cancers.88, 89, 90, 91, 92 Recently, a phase 1 and 2 clinical trial was completed to study the optimal dosing for the BETi molibresib in patients with solid tumors, including NSCLCs and SCLCs
Appl Mater Today
Active sites of thioredoxin reductases: why selenoproteins
