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500 mcg per day of vitamin B12 (cobalamin or methylcobalamin)
Those are among others, tumour angiogenesis, and neovascularization [18], immunosuppressive tumour microenvironment [19], promotion of epithelial-to-mesenchymal transition (EMT) and malignancy [2022], and induction of resistance to chemo- and radiotherapy-induced cell death [23] as well as to immunotherapy [24]
Among the upregulated genes are those encoding DNA repair enzymes (BRCA1, ATM), extracellular matrix proteins (COL1A1, COL3A1, ELN) and antioxidant enzymes (SOD1, SOD2, GPX)
Medicines 6(3): 95
