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In vitro results are a promising starting point, but skin is far more complex than a dish, so they don't automatically translate into visible results on your face

The graphical summary presented in Figure 3 illustrates how both direct and indirect pathways lead to the pathological alterations of the actin cytoskeleton in FRDA

For four of these metabolites (homotaurine, N -acetyl-phenylalanylleucine/isoleucine, 3-hydroxypropane-1-sulfonic acid, and N 1 -methyl-imidazolelactic acid), the chemical standard did not match to the original tissue peak, but instead matched a peak with a distinct MS/MS spectrum and/or a retention time difference that could not be explained by chromatographic drift (see also Success rate of metabolite discovery)

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