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Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies

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These abnormalities involve the following aspects: increased inflammatory responses, such as matrix catabolism induced by interleukin-1 (IL-1 ) and TNF , as well as impairment of chondrocyte growth and anabolic responses, excessive oxidative stress, apoptosis of chondrocytes, and calcification of the cartilage matrix (112, 119)

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