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Evidence has shown that 8 weeks of aerobic exercise significantly activates the System Xc /GPX4 signaling axis in the prefrontal cortex of AD mice, upregulates ferritin light chain (FTL) and -site amyloid precursor protein cleaving enzyme 1 (BACE1), downregulates 4-hydroxynonenal (4-HNE), inhibits ferroptosis and lipid peroxidation, and ameliorates cognitive deficits (Li et al., 2024a)

As shown in Figure 37.5 , when OH abstracts a hydrogen atom from a PUFA, it initiates a chain of lipid peroxidation reaction, producing secondary oxidation products, lipid peroxides and lipid peroxyl radicals

doi: 10.1111/j.1432-1033.1969.tb00488.x

Acute illness may be missed unless schistosomiasis is suspected