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All these risks were found to be independent of factors such as age, sex, T2DM, obesity, and smoking

Comparing the tablet form of the preparation with the topical preparation for skin application, it is worth noting that in the case of the oral drug, the active substance acts systemically, where it passes through the digestive tract, penetrates into the patient's blood, and is excreted through the kidneys

doi: 10.1038/nchembio.1611 [DOI] [PMC free article] [PubMed] [Google Scholar] 232.Irannejad R, Tomshine JC, Tomshine JR, Chevalier M, Mahoney JP, Steyaert J, Rasmussen SG, Sunahara RK, El-Samad H, Huang B, et al

Crucially, epigenetics acts as the interface between your genes and your environment, meaning that factors like stress, diet, sleep, and toxin exposure can alter gene expression without changing the underlying DNA code [31]