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Nat Rev Neurosci (2018) 19(4):23549
One of the downstream effects of Abcb10 loss is the activation of a nutrient stress response mediated by the transcription factor ATF4, which regulates the expression of various genes involved in the cellular stress response
In the CNS, AIM2 expression has been detected in microglia and astrocytes, and AIM2 activation has been linked to neuroinflammatory responses and cognitive deficits in experimental models of neurodegeneration and traumatic brain injury
