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However, azoles are less effective for aspergillosis or systemic yeast infections, and long-term use may result in hepatotoxicity, though they are generally better tolerated than polyenes ( ERG11 , reducing azole binding to the target enzyme (Lee et al., 2021)
High prolactin (less common): missed periods, headaches Illness Or Recent Infection Fever or recovery can delay ovulation
doi: 10.1128/CDLI.7.6.920-924.2000 32 TeskeyG.AbrahemR.CaoR.GyurjianK.IslamogluH.LuceroM.et al
and methaemoglobinaemia makes the tissue hypoxia consequent on anaemia more severe, because methaemoglobin does not carry oxygen
