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These alterations were successfully corrected by the treatment with an antibody against C5aR1 (C5aR1 Ab) or with a C5aR1 antagonist, thus demonstrating the crucial role of C5aR1 in the mediation of paclitaxel neurotoxicity in vitro and that the inhibition of C5aR1 can effectively counteract paclitaxel downstream neuropathological effects

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Although Werner Kuhn (18991963) demonstrated the possibilities of studying molecular structure by ORD in 1929 (Kuhn, 1929), the actual exploration of these possibilities started much later

Calcium signalling: dynamics, homeostasis and remodelling