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Incomplete healing as a cause of aging: the role of mitochondria and the cell danger response

The truncation reduces IGFBP binding similar to the LR3 modification, but DES IGF-1 retains a much shorter circulating half-life (typically reported in the 20 to 30 minute range) because the rest of the molecule remains susceptible to standard proteolytic clearance
Mallbris L, Granath F, Hamsten A, Stahle M
, Has, K