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Acta Physiol (Oxf) 2021;232:e13644

2APB: 2-aminoethoxydipenyl-borate APAP: acetaminophen DAMPs: damage-associated molecular patterns DMSO: dimethyl sulfoxide GSH: glutathione LDH: lactate dehydrogenase LPO: lipid peroxidation MPTP: mitochondrial membrane permeability transition pore NAC: N -acetylcysteine NK: natural killer NNT: nicotinamide nucleotide transhydrogenase P-JNK: phosphorylation of c-jun N-terminal kinase PUFAs: polyunsaturated fatty acids ROS: reactive oxygen species SEC: sinusoidal endothelial cell HJ: Conceptualization, Writingoriginal draft, Writingreview & editing

This study was funded by the NIH/NCI grants P01 CA168585, R21 CA169993, R35 CA197633, and R01 CA170689, and by the Parker Institute for Cancer Immunotherapy