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This study demonstrated that T FH cells and IL-21 are overproduced in T1D, challenging the established T H 1 paradigm

Kim JE, Glassman AR, Josic K, et al

When the gr overexpression strain was compared with the control strain (wild type carrying plasmid pJRD215), the expression levels of glutathione reductase and heterodisulfide reductase subunit C were increased after incubation for 1 and 2 h, respectively, while the expression levels of thioredoxin-disulfide reductase and sulfur dioxygenase were decreased after incubation for 1 h, and the expression levels of peroxiredoxin were decreased after incubation for 2 h, respectively

Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis