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1 Introduction DOR is characterized by a reduction in the number and/or quality of oocytes, leading to insufficient ovarian function, sex hormone deficiency, and decreased fertility

The clinical picture that kisspeptin targets best: Women with PMOS who are anovulatory Women who have not responded to standard ovulation induction (clomiphene, letrozole) Women in whom the central hormonal disruption not just insulin resistance is the dominant feature This is not a standalone treatment