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Whilst individual responses vary, the potential for artificial sweeteners to compromise hair health through inflammation, oxidative stress, and nutrient depletion warrants serious consideration

[212] There is growing appreciation of the importance of the pleiotropic hormone vitamin D in the development of tolerance, immune system defenses, and epithelial barrier integrity [213] 1,25(OH)2D3 (vitamin D) may play a protective role in mucosal barrier homeostasis by maintaining the integrity of junction complexes and in healing capacity of the colon epithelium

Antioxidant and anti-inflammatory substances, such as D-mannose, icaritin (162) and Fer-1, inhibit ferroptosis in chondrocytes by regulating the GPX4 pathway, thereby slowing cartilage degeneration and decelerating the pathological process of OA (80, 163)