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In contrast, unilateral reactivation markedly improved hyperinsulinemia and normalized blood glucose levels and locomotor activity (Coppari et al., In the other study, the expression of ObRb only in POMC neurons leads to a marked decrease in energy intake and a modest reduction in body weight (Huo et al., Leptin and insulin signaling regulate food intake by controlling the expression of orexigenic and anorexigenic neuropeptides in ARH via FoxO1 and the STAT-3

Nikolaev AA, Lutski DL, Nikolaeva NN, Lozhkina LV