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Here, we identify FOXO4 as a pivot in senescent cell viability
Wolf CR, Hayward IP, Lawrie SS, Buckton K, McIntyre MA, Adams DJ, Lewis AD, Scott AR and Smyth JF
10.1016/j.colsurfb.2007.09.009 [DOI] [PubMed] [Google Scholar] Helmbacher F., Dessaud E., Arber S., DeLapeyrire O., Henderson C
However, in a starvation situation, mTOR is deactivated, which allows ULK (the mammalian counterpart of the yeast protein ATG1) to become activated and translocate to the endoplasmic reticulum, initiating the autophagy cascade
