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Review of current strategies for delivering Alzheimers disease drugs across the blood-brain barrier

52 For an ideal assessment of the type, quantity, and frequency of food intake, real-time monitoring would be preferable over methods such as 24-hour dietary recalls or short-term measurements of food consumption

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This suggests that therapeutic research focusing on DYRK1A inhibition should, at least in part, also take care of the problem of CBS triplication, at the condition that these inhibitors are specific of DYRK1A and do not inhibit GSK3 as well, as our data suggest that GSK3 activation is needed to reduce Nrf2 activity and thus CBS expression