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A 3-plane scout image set quickly determined the patients position within the coil, followed by high-contrast, T1-weighted sagittal and axial image sets (TE/TR = 6.2/11.4 milliseconds, field of view = 22 22 cm, readout duration = 4 milliseconds, receive bandwidth = 32 kHz, in-plane matrix size = 128 256 [sagittal], 256 256 [axial], in-plane resolution = 1.90 0.94 mm [sagittal], 0.94 0.94 mm [axial], axial-plane matrix size = 32 [sagittal], 64 [axial] axial-plane resolution = 2.5 mm [sagittal and axial], scan time = 2 minutes, 30 seconds [sagittal], 5 minutes [axial]) of the entire brain were acquired using a 3-dimensional, magnetization-prepared FLASH imaging sequence (3D-mpFLASH), allowing for clear segmentation between gray matter, white matter, and CSF

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Once formed, AGEs can damage cellular structures through a number of mechanisms, including the formation of cross-links between key molecules of the basement membrane of the extracellular matrix and interaction with receptors on cell surfaces, leading to this way to alteration of cellular function [36, 37]