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A major advance came in 1913, when Santiago Ramn y Cajal, using the gold-sublimate method, described two key astrocyte subtypes: Protoplasmic astrocytes, found in grey matter and marked by fine, elaborate processes, and fibrous astrocytes, present in white matter and distinguished by longer, fiber-like extensions

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During the initial phase (the first ~5 years), patients typically experience a wide therapeutic window with smooth and dramatic improvements in motor symptoms following each dose