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Metalloproteinase 17 (ADAM17) mediates the inflammatory response by releasing biologically active inflammatory cytokines and mediators, including tumor necrosis factor (TNF) and soluble IL-6 receptor (sIL-6R), which drives trans-signaling of pro-inflammatory IL-6

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A confirmatory dose-ranging study of riluzole in ALS

Actual bacterial fragments are getting into your brain and triggering inflammation there Inflammation is upstream of basically every major disease: type 2 diabetes, cancer, Alzheimers, frailty