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These findings suggested that busulfan can significantly induce ROS creation and reduce antioxidants, leading to oxidative stress and lipid peroxidation in testicular tissue, which, in turn, can result in germ cell death, spermatogenesis impairment, and infertility (49)

Additionally, the vascular endothelium (the inner lining of the blood vessels) requires significant energy to produce nitric oxide, a molecule essential for regulating blood vessel dilation and constriction

Reliability and validity studies of the WHO-Composite International Diagnostic Interview (CIDI): a critical review

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