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, liver or kidney), a particular metabolic pathway, or the whole body
The total amount of active ingredient in the vial is unchanged
It was moderately inhibited with Lithocholic acid, Hematin and Triphenyltin chloride
One of them, (R)-PFI-2, inhibits the methyltransferase activity of Set7/9 at nanomolar concentrations and does not exhibit toxicity at an effective concentration in human cells 179 , 180
