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doi: 10.1016/j.abb.2010.03.019

The FDA guidance published in 1993 left the decision of including women of childbearing potential up to the researchers, IRBs, and women enrolling in the trial.34 In 1998, the FDA provided an updated guidance on the topic mandating sponsors to understand sex differences in PK, safety, and pharmacological response

Several studies have shown that AtZAT10 overexpression, knockout, and RNAi mutants displayed enhanced resistance to drought-, osmotic-, and salt stresses, highlighting its dual role in response to environmental stresses (Sakamoto et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 56.Lin C.Y., Wu J.L., Shih T.S., Tsai P.J., Sun Y.M., Ma M.C., Guo Y.L