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Zhu WY, Alliegro MA, Melera PW (2001) The rate of folate receptor alpha (FR alpha) synthesis in folate depleted CHL cells is regulated by a translational mechanism sensitive to media folate levels, while stable overexpression of its mRNA is mediated by gene amplification and an increase in transcript half-life

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Figure 3 illustrates this idea by showing how a combination of various tools creates a possibility to see the whole elephant by integrating the different structural details of IDPs, such as shape, packing, secondary structure, flexibility, hydrodynamic properties, solvent accessibility, conformational heterogeneity, and self-assembly