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doi: 10.1016/s0140-6736(18)31268-6 27 IslamSUeharaOMatsuokaHKuramitsuYAdhikariBRHirakiDet al
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Therefore, HIF-1 likely exerts a suppressive effect on ferroptosis in affected cells by upregulating antioxidant systems, exerting a protective role similar to its anti-apoptotic effects in osteoblasts
GPX4 reduces phospholipid hydroperoxides (PL-OOH) to their corresponding non-toxic phospholipid alcohol (PL-OH) using GSH as an electron donor, thereby preserving membrane integrity 95
