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In GBM, the metabolic profiling of GBM cell lines showed that the abundance of GTP nucleotides correlates with resistance to radiation therapy, while inhibition of GTP synthesis sensitized GBM cells to irradiation by impairing DNA repair [84]
The relationship between ATM and redox stress sensing was further evidenced as we observed that the inhibition of ATM expression by chemical inhibition promoted the loss of melanocyte viability induced by oxidative stress
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[DOI] [PubMed] [Google Scholar] 68.Fan H., Chen K., Duan L., Wang Y.Z., Ju G
